Carrier Size, Surface and Geometry: New Tools to Provide a Mechanistic Understanding of Interactive Powder Blends
Scherließ R, Majid Z, Wostry M.
Respiratory Drug Delivery 2025. Volume 1, 2025: 8-17.
Abstract:
This study investigates how carrier particle properties affect dry powder inhalation performance, focusing on carrier surface energy and carrier geometry. Modifying lactose surface energy via silanization and different forms of magnesium stearate showed that surface energy changes alone do not guarantee better drug delivery, highlighting the importance of other factors. To isolate the impact of geometry, computer simulations and 3D-printed particles with defined shapes were utilized. The simulations of drug detachment during collisions correlated with experimental results of fine particle fraction (FPF), demonstrating that carrier shape significantly influences drug dispersion. This work introduces new methods for understanding the complex interplay of carrier properties, paving the way for designing more effective inhalation therapies through rational, science-based approaches.
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