Shaping the Future of Inhaled Powders: Spray-Drying siRNA Lipid Nanoparticles for Dry Powder Pulmonary Delivery
Merkel O.
Respiratory Drug Delivery 2023. Volume , 2023: 113-124.
Abstract:
RNA medicines are on the rise but thwarted by one major hurdle: delivery. Spray-drying RNA nanoparticles permit new delivery opportunities including pulmonary delivery via inhalation, in addition to enabling improved storage stability for all routes of administration. Therefore, the need for spray-dried formulations, their potential, the technical challenges, cell targeting within the lungs and biodistribution of the final formulations are discussed in this article. As a therapeutic molecule with endless applications, RNA may be the solution to many currently ‘undruggable’ diseases. But to deliver it to the lung, suitable formulations are needed, and spray-drying is a valuable approach to achieve this aim. As a thermolabile molecule, RNA requires special attention, however, and nanoparticle aggregation under thermal and shear stress must be avoided. The latest advancements in spray-dried RNA nanoparticles are discussed and further technical optimization is proposed.
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