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In Vitro and In Vivo Assessment of Regional Nasal Deposition using Scintigraphy from a Nasal Spray and a Nasal Powder

Williams G, Cabrera M, Graine L, Le Guellec S, Hauchard N, Jamar F, Pardessus J, Le Pennec D, Reychler G.

Respiratory Drug Delivery 2021. Volume , 2021: 135-140.

Abstract:

Case studies which utilized scintigraphy to link in vitro and in vivo nasal spray deposition from a nasal spray and a powder were undertaken. In vitro deposition in a nasal cast illustrated that significantly higher deposition (p<0.05) was observed in the olfactory region for the unit-dose powder device compared to the multi-dose liquid nasal spray pump. In vivo studies in healthy volunteers also demonstrated increased deposition in the olfactory region for the nasal powder compared to the nasal spray.

Coupling in vitro and in vivo nasal deposition has the potential to provide valuable insight into the utility of in vitro studies to inform subsequent clinical studies during the development of nasal drug delivery therapies, whether they be local or systemic.