New Frontiers in Respiratory Drug Delivery: Stem Cells as Targets and Therapies
Lee RE, Randell SH.
Respiratory Drug Delivery 2018. Volume 1, 2018: 7-22.
Abstract:
Small molecules currently dominate inhaled therapies, with a few peptide/protein examples. However, there is enthusiasm for a future including cell therapy, and targeting stem cells in the lung, for respiratory tract regenerative medicine. Cellular transplantation to reconstitute the hematopoietic system is standard practice, and progress has been made in certain solid organs. Rational approaches to harness stem cells for respiratory tract regenerative medicine are predicated on basic knowledge. Cellular complexity and normally quiescent, but inducible cell proliferation after injury has stifled lung stem cell research. However, there has been considerable recent progress. Herein, we concisely summarize key aspects of the expansive subject of stem cell focused therapies applicable to the lungs. We highlight challenges such as cell delivery, engraftment, and delivery of molecules or vehicles intended to target stem cells.
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