Targeting TB Treatment: Antimicrobial Peptide Delivery Using Hyaluronic Acid Nanogels
Gama M, Silva JP, Silva-Carvalho R, Goncalves C, Sousa J, Silva-Gomes R, Castro AG, Pedrosa J, Appelberg R.
RDD Asia 2016. Volume , 2016: 71-80.
Abstract:
Tuberculosis (TB), a disease caused by the pathogen Mycobacterium tuberculosis, is among the deadliest infectious diseases. Its prevention through vaccination is still very limited and current treatments rely on prolonged, multiple antibiotic therapies that often result in low patient compliance, treatment failure, and emergence of Multidrug-resistant (MDR) strains.
The search for more efficient anti-TB drugs associated with the great therapeutic potential of antimicrobial peptides (AMPs) provides an optimal environment for the development of promising therapies. In this investigation, the potential of LLKKK18-loaded self-assembling hyaluronic nanogels as TB therapeutics is presented.
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