Understanding the Mechanics of Powder Dispersion in Dry Powder Inhalers
Chan H, Tong Z, Zhou T, Leung CM, Yu A, Yang R.
RDD Asia 2016. Volume , 2016: 1-14.
Abstract:
Advances in understanding of powder properties and dispersion mechanics can facilitate improved design of dry powder inhaler (DPI) products by progressing beyond empirical approaches to enhance the aerosol performance. Experimental measurements using impaction or laser diffraction methods can provide useful information on the overall aerosolization performance of powder formulations, but these approaches are not sufficient for understanding the mechanism of powder dispersion in DPIs. This is because the dispersion process involves inter-related interactions between the powder formulation, inhaler device, and airflow that are not easily measured at the length and time scales encountered during DPI aerosolization. Our group has attempted to understand DPI dispersion through a series of systematic, fundamental studies using Aerolizer® as the model device with various types of formulations. This article summarizes some of our efforts to address the complexity of DPI design from a formulation and device perspective using a combination of experimental and computational approaches.
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